SHANK3 controls maturation of social reward circuits in the VTA

Haploinsufficiency of SHANK3, encoding the synapse scaffolding protein SHANK3, leads to a highly penetrant form of Autism Spectrum Disorder (ASD). How SHANK3 insufficiency affects specific neural circuits and this is related to specific ASD symptoms remains elusive. Here we used shRNA to model Shank...

Descripción completa

Detalles Bibliográficos
Autores principales: Bariselli, Sebastiano, Tzanoulinou, Stamatina, Glangetas, Christelle, Prévost-Solié, Clément, Pucci, Luca, Viguié, Joanna, Bezzi, Paola, O’Connor, Eoin C., Georges, François, Lüscher, Christian, Bellone, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948673/
https://www.ncbi.nlm.nih.gov/pubmed/27273769
http://dx.doi.org/10.1038/nn.4319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948673/
https://www.ncbi.nlm.nih.gov/pubmed/27273769
http://dx.doi.org/10.1038/nn.4319

Ejemplares similares