Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy

Tumor vessels are characterized by abnormal morphology and hyper-permeability that together cause inefficient delivery of chemotherapeutic agents. Although VEGF has been established as a critical regulator of tumor angiogenesis, the role of mechanical signaling in the regulation of tumor vasculature...

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Detalles Bibliográficos
Autores principales: Adapala, Ravi K., Thoppil, Roslin J., Ghosh, Kaustabh, Cappelli, Holly, Dudley, Andrew C., Paruchuri, Sailaja, Keshamouni, Venkateshwar, Klagsbrun, Michael, Meszaros, J. Gary, Chilian, William M., Ingber, Donald E., Thodeti, Charles K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948740/
https://www.ncbi.nlm.nih.gov/pubmed/25867067
http://dx.doi.org/10.1038/onc.2015.83

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948740/
https://www.ncbi.nlm.nih.gov/pubmed/25867067
http://dx.doi.org/10.1038/onc.2015.83

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