PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells

Poly(ADP-ribose) polymerases (PARPs) are the first proteins involved in cellular DNA repair pathways to be targeted by specific inhibitors for clinical benefit. Tumors harboring genetic defects in homologous recombination (HR), a DNA double-strand break (DSB) repair pathway, are hypersensitive to PA...

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Detalles Bibliográficos
Autores principales: Ito, Shuhei, Murphy, Conleth G., Doubrovina, Ekaterina, Jasin, Maria, Moynahan, Mary Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948780/
https://www.ncbi.nlm.nih.gov/pubmed/27428646
http://dx.doi.org/10.1371/journal.pone.0159341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948780/
https://www.ncbi.nlm.nih.gov/pubmed/27428646
http://dx.doi.org/10.1371/journal.pone.0159341

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