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PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells

Poly(ADP-ribose) polymerases (PARPs) are the first proteins involved in cellular DNA repair pathways to be targeted by specific inhibitors for clinical benefit. Tumors harboring genetic defects in homologous recombination (HR), a DNA double-strand break (DSB) repair pathway, are hypersensitive to PA...

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Detalles Bibliográficos
Autores principales:	Ito, Shuhei, Murphy, Conleth G., Doubrovina, Ekaterina, Jasin, Maria, Moynahan, Mary Ellen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948780/ https://www.ncbi.nlm.nih.gov/pubmed/27428646 http://dx.doi.org/10.1371/journal.pone.0159341

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