Context Matters: Distinct Disease Outcomes as a Result of Crebbp Hemizygosity in Different Mouse Bone Marrow Compartments

Perturbations in CREB binding protein (CREBBP) are associated with hematopoietic malignancies, including myelodysplastic syndrome (MDS). Mice hemizygous for Crebbp develop myelodysplasia with proliferative features, reminiscent of human MDS/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U), and...

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Detalles Bibliográficos
Autores principales: Zhou, Ting, Perez, Stephanie N., Cheng, Ziming, Kinney, Marsha C., Lemieux, Madeleine E., Scott, Linda M., Rebel, Vivienne I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948888/
https://www.ncbi.nlm.nih.gov/pubmed/27427906
http://dx.doi.org/10.1371/journal.pone.0158649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948888/
https://www.ncbi.nlm.nih.gov/pubmed/27427906
http://dx.doi.org/10.1371/journal.pone.0158649

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