APOBEC3DE Inhibits LINE-1 Retrotransposition by Interacting with ORF1p and Influencing LINE Reverse Transcriptase Activity

Human long interspersed elements 1 (LINE-1 or L1) is the only autonomous non-LTR retroelement in humans and has been associated with genome instability, inherited genetic diseases, and the development of cancer. Certain human APOBEC3 family proteins are known to have LINE-1 restriction activity. The...

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Detalles Bibliográficos
Autores principales: Liang, Weizi, Xu, Jiwei, Yuan, Wensu, Song, Xuan, Zhang, Jianyong, Wei, Wei, Yu, Xiao-Fang, Yang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948907/
https://www.ncbi.nlm.nih.gov/pubmed/27428332
http://dx.doi.org/10.1371/journal.pone.0157220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948907/
https://www.ncbi.nlm.nih.gov/pubmed/27428332
http://dx.doi.org/10.1371/journal.pone.0157220

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