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Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs
Ribosomal attachment to mammalian capped mRNAs is achieved through the cap–eukaryotic initiation factor 4E (eIF4E)–eIF4G–eIF3–40S chain of interactions, but the mechanism by which mRNA enters the mRNA-binding channel of the 40S subunit remains unknown. To investigate this process, we recapitulated i...
Autores principales: | Kumar, Parimal, Hellen, Christopher U.T., Pestova, Tatyana V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949329/ https://www.ncbi.nlm.nih.gov/pubmed/27401559 http://dx.doi.org/10.1101/gad.282418.116 |
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