A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

Precise regulation of centrosome number is critical for accurate chromosome segregation and the maintenance of genomic integrity. In nontransformed cells, centrosome loss triggers a p53-dependent surveillance pathway that protects against genome instability by blocking cell growth. However, the mech...

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Detalles Bibliográficos
Autores principales: Lambrus, Bramwell G., Daggubati, Vikas, Uetake, Yumi, Scott, Phillip M., Clutario, Kevin M., Sluder, Greenfield, Holland, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949452/
https://www.ncbi.nlm.nih.gov/pubmed/27432896
http://dx.doi.org/10.1083/jcb.201604054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949452/
https://www.ncbi.nlm.nih.gov/pubmed/27432896
http://dx.doi.org/10.1083/jcb.201604054

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