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A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis
Precise regulation of centrosome number is critical for accurate chromosome segregation and the maintenance of genomic integrity. In nontransformed cells, centrosome loss triggers a p53-dependent surveillance pathway that protects against genome instability by blocking cell growth. However, the mech...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949452/ https://www.ncbi.nlm.nih.gov/pubmed/27432896 http://dx.doi.org/10.1083/jcb.201604054 |