Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ

Mammalian p38 mitogen activated protein kinases (MAPKs) are responsive to a variety of cellular stresses. The development of specific pyridinyl imidazole inhibitors has permitted the characterization of the p38 MAPK isoform p38α, which is expressed in most cell types, whereas the physiological roles...

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Detalles Bibliográficos
Autores principales: Kondoh, Yasumitsu, Honda, Kaori, Hiranuma, Sayoko, Hayashi, Teruo, Shimizu, Takeshi, Watanabe, Nobumoto, Osada, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949465/
https://www.ncbi.nlm.nih.gov/pubmed/27431267
http://dx.doi.org/10.1038/srep29881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949465/
https://www.ncbi.nlm.nih.gov/pubmed/27431267
http://dx.doi.org/10.1038/srep29881

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