Cardiac glycosides display selective efficacy for STK11 mutant lung cancer

Although STK11 (LKB1) mutation is a major mediator of lung cancer progression, targeted therapy has not been implemented due to STK11 mutations being loss-of-function. Here, we report that targeting the Na(+)/K(+)-ATPase (ATP1A1) is synthetic lethal with STK11 mutations in lung cancer. The cardiac g...

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Detalles Bibliográficos
Autores principales: Kim, Nayoung, Yim, Hwa Young, He, Ningning, Lee, Cheol-Jung, Kim, Ju Hyun, Choi, Jin-Sung, Lee, Hye Suk, Kim, Somin, Jeong, Euna, Song, Mee, Jeon, Sang-Min, Kim, Woo-Young, Mills, Gordon B., Cho, Yong-Yeon, Yoon, Sukjoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949473/
https://www.ncbi.nlm.nih.gov/pubmed/27431571
http://dx.doi.org/10.1038/srep29721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949473/
https://www.ncbi.nlm.nih.gov/pubmed/27431571
http://dx.doi.org/10.1038/srep29721

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