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Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications
The natural product staurosporine is a high‐affinity inhibitor of nearly all mammalian protein kinases. The labelling of staurosporine has proven effective as a means of generating protein kinase research tools. Most tools have been generated by acylation of the 4′‐methylamine of the sugar moiety of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949516/ https://www.ncbi.nlm.nih.gov/pubmed/27008372 http://dx.doi.org/10.1002/cmdc.201500589 |