Reduced TCR‐dependent activation through citrullination of a T‐cell epitope enhances Th17 development by disruption of the STAT3/5 balance

Citrullination is a post‐translational modification of arginine that commonly occurs in inflammatory tissues. Because T‐cell receptor (TCR) signal quantity and quality can regulate T‐cell differentiation, citrullination within a T‐cell epitope has potential implications for T‐cell effector function....

Descripción completa

Detalles Bibliográficos
Autores principales: Tibbitt, Christopher, Falconer, Jane, Stoop, Jeroen, van Eden, Willem, Robinson, John H., Hilkens, Catharien M.U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Adaptive Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949576/
https://www.ncbi.nlm.nih.gov/pubmed/27173727
http://dx.doi.org/10.1002/eji.201546217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949576/
https://www.ncbi.nlm.nih.gov/pubmed/27173727
http://dx.doi.org/10.1002/eji.201546217

Ejemplares similares