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Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals
A substantial proportion of schizophrenia liability can be explained by additive genetic factors. Risk profile scores (RPS) directly index risk using a summated total of common risk variants weighted by their effect. Previous studies suggest that schizophrenia RPS predict alterations to neural netwo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949629/ https://www.ncbi.nlm.nih.gov/pubmed/26510167 http://dx.doi.org/10.1002/hbm.23044 |
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author | Lancaster, Thomas M. Ihssen, Niklas Brindley, Lisa M. Tansey, Katherine E. Mantripragada, Kiran O'Donovan, Michael C. Owen, Michael J. Linden, David E.J. |
author_facet | Lancaster, Thomas M. Ihssen, Niklas Brindley, Lisa M. Tansey, Katherine E. Mantripragada, Kiran O'Donovan, Michael C. Owen, Michael J. Linden, David E.J. |
author_sort | Lancaster, Thomas M. |
collection | PubMed |
description | A substantial proportion of schizophrenia liability can be explained by additive genetic factors. Risk profile scores (RPS) directly index risk using a summated total of common risk variants weighted by their effect. Previous studies suggest that schizophrenia RPS predict alterations to neural networks that support working memory and verbal fluency. In this study, we apply schizophrenia RPS to fMRI data to elucidate the effects of polygenic risk on functional brain networks during a probabilistic‐learning neuroimaging paradigm. The neural networks recruited during this paradigm have previously been shown to be altered to unmedicated schizophrenia patients and relatives of schizophrenia patients, which may reflect genetic susceptibility. We created schizophrenia RPS using summary data from the Psychiatric Genetic Consortium (Schizophrenia Working Group) for 83 healthy individuals and explore associations between schizophrenia RPS and blood oxygen level dependency (BOLD) during periods of choice behavior (switch–stay) and reflection upon choice outcome (reward–punishment). We show that schizophrenia RPS is associated with alterations in the frontal pole (P (WHOLE‐BRAIN‐CORRECTED) = 0.048) and the ventral striatum (P (ROI‐CORRECTED )= 0.036), during choice behavior, but not choice outcome. We suggest that the common risk variants that increase susceptibility to schizophrenia can be associated with alterations in the neural circuitry that support the processing of changing reward contingencies. Hum Brain Mapp 37:491–500, 2016. © 2015 Wiley Periodicals, Inc. |
format | Online Article Text |
id | pubmed-4949629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49496292016-07-28 Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals Lancaster, Thomas M. Ihssen, Niklas Brindley, Lisa M. Tansey, Katherine E. Mantripragada, Kiran O'Donovan, Michael C. Owen, Michael J. Linden, David E.J. Hum Brain Mapp Research Articles A substantial proportion of schizophrenia liability can be explained by additive genetic factors. Risk profile scores (RPS) directly index risk using a summated total of common risk variants weighted by their effect. Previous studies suggest that schizophrenia RPS predict alterations to neural networks that support working memory and verbal fluency. In this study, we apply schizophrenia RPS to fMRI data to elucidate the effects of polygenic risk on functional brain networks during a probabilistic‐learning neuroimaging paradigm. The neural networks recruited during this paradigm have previously been shown to be altered to unmedicated schizophrenia patients and relatives of schizophrenia patients, which may reflect genetic susceptibility. We created schizophrenia RPS using summary data from the Psychiatric Genetic Consortium (Schizophrenia Working Group) for 83 healthy individuals and explore associations between schizophrenia RPS and blood oxygen level dependency (BOLD) during periods of choice behavior (switch–stay) and reflection upon choice outcome (reward–punishment). We show that schizophrenia RPS is associated with alterations in the frontal pole (P (WHOLE‐BRAIN‐CORRECTED) = 0.048) and the ventral striatum (P (ROI‐CORRECTED )= 0.036), during choice behavior, but not choice outcome. We suggest that the common risk variants that increase susceptibility to schizophrenia can be associated with alterations in the neural circuitry that support the processing of changing reward contingencies. Hum Brain Mapp 37:491–500, 2016. © 2015 Wiley Periodicals, Inc. John Wiley and Sons Inc. 2015-10-28 /pmc/articles/PMC4949629/ /pubmed/26510167 http://dx.doi.org/10.1002/hbm.23044 Text en © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Lancaster, Thomas M. Ihssen, Niklas Brindley, Lisa M. Tansey, Katherine E. Mantripragada, Kiran O'Donovan, Michael C. Owen, Michael J. Linden, David E.J. Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals |
title | Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals |
title_full | Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals |
title_fullStr | Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals |
title_full_unstemmed | Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals |
title_short | Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals |
title_sort | associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949629/ https://www.ncbi.nlm.nih.gov/pubmed/26510167 http://dx.doi.org/10.1002/hbm.23044 |
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