Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer’s disease

BACKGROUND: Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer’s disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology o...

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Detalles Bibliográficos
Autores principales: Thomas, Rhian S., Henson, Alex, Gerrish, Amy, Jones, Lesley, Williams, Julie, Kidd, Emma J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949774/
https://www.ncbi.nlm.nih.gov/pubmed/27430330
http://dx.doi.org/10.1186/s12868-016-0288-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949774/
https://www.ncbi.nlm.nih.gov/pubmed/27430330
http://dx.doi.org/10.1186/s12868-016-0288-1

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