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Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors
[Image: see text] Available crystal structures of opioid receptors provide a high-resolution picture of ligand binding at the primary (“orthosteric”) site, that is, the site targeted by endogenous ligands. Recently, positive allosteric modulators of opioid receptors have also been discovered, but th...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950826/ https://www.ncbi.nlm.nih.gov/pubmed/26841170 http://dx.doi.org/10.1021/acschembio.5b00712 |