Targeting the RB-E2F pathway in breast cancer

Mutations of the retinoblastoma tumor suppressor gene (RB1) or components regulating the CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re-establishing cell cycle control through CDK inhibition has therefore emerged as an attractive option in the development of targeted ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Johnson, Jackie, Thijssen, Bram, McDermott, Ultan, Garnett, Mathew, Wessels, Lodewyk F.A., Bernards, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950965/
https://www.ncbi.nlm.nih.gov/pubmed/26923330
http://dx.doi.org/10.1038/onc.2016.32

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950965/
https://www.ncbi.nlm.nih.gov/pubmed/26923330
http://dx.doi.org/10.1038/onc.2016.32

Ejemplares similares