High Glucose Impairs Insulin Signaling in the Glomerulus: An In Vitro and Ex Vivo Approach

OBJECTIVE: Chronic hyperglycaemia, as seen in type II diabetes, results in both morphological and functional impairments of podocytes in the kidney. We investigated the effects of high glucose (HG) on the insulin signaling pathway, focusing on cell survival and apoptotic markers, in immortalized hum...

Descripción completa

Detalles Bibliográficos
Autores principales: Katsoulieris, Elias N., Drossopoulou, Garyfalia I., Kotsopoulou, Eleni S., Vlahakos, Dimitrios V., Lianos, Elias A., Tsilibary, Effie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951020/
https://www.ncbi.nlm.nih.gov/pubmed/27434075
http://dx.doi.org/10.1371/journal.pone.0158873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951020/
https://www.ncbi.nlm.nih.gov/pubmed/27434075
http://dx.doi.org/10.1371/journal.pone.0158873

Ejemplares similares