Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis

One of the most frequently deregulated signaling pathways in breast cancer is the PI 3-K/Akt cascade. Genetic lesions are commonly found in PIK3CA, PTEN, and AKT, which lead to excessive and constitutive activation of Akt and downstream signaling that results in uncontrolled proliferation and increa...

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Detalles Bibliográficos
Autores principales: Mancini, Maria L., Lien, Evan C., Toker, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951213/
https://www.ncbi.nlm.nih.gov/pubmed/27004402
http://dx.doi.org/10.18632/oncotarget.8191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951213/
https://www.ncbi.nlm.nih.gov/pubmed/27004402
http://dx.doi.org/10.18632/oncotarget.8191

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