Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

Intracellular accumulation of wild type tau is a hallmark of sporadic Alzheimer's disease (AD). However, the molecular mechanisms underlying tau toxicity is not fully understood. Here, we detected mitophagy deficits evidenced by the increased levels of mitophagy markers, including COX IV, TOMM2...

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Detalles Bibliográficos
Autores principales: Hu, Yu, Li, Xia-Chun, Wang, Zhi-hao, Luo, Yu, Zhang, Xiangnan, Liu, Xiu-Ping, Feng, Qiong, Wang, Qun, Yue, Zhenyu, Chen, Zhong, Ye, Keqiang, Wang, Jian-Zhi, Liu, Gong-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951217/
https://www.ncbi.nlm.nih.gov/pubmed/26943044
http://dx.doi.org/10.18632/oncotarget.7861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951217/
https://www.ncbi.nlm.nih.gov/pubmed/26943044
http://dx.doi.org/10.18632/oncotarget.7861

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