Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer

The expression of the tumor suppressor Merlin is compromised in nervous system malignancies due to genomic aberrations. We demonstrated for the first time, that in breast cancer, Merlin protein expression is lost due to proteasome-mediated elimination. Immunohistochemical analysis of tumor tissues f...

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Detalles Bibliográficos
Autores principales: Morrow, K. Adam, Das, Shamik, Meng, Erhong, Menezes, Mitchell E., Bailey, Sarah K., Metge, Brandon J., Buchsbaum, Donald J., Samant, Rajeev S., Shevde, Lalita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951266/
https://www.ncbi.nlm.nih.gov/pubmed/26908451
http://dx.doi.org/10.18632/oncotarget.7494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951266/
https://www.ncbi.nlm.nih.gov/pubmed/26908451
http://dx.doi.org/10.18632/oncotarget.7494

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