An EBV recombinant deleted for residues 130-159 in EBNA3C can deregulate p53/Mdm2 and Cyclin D1/CDK6 which results in apoptosis and reduced cell proliferation

Epstein-Barr virus (EBV), a gamma herpes virus is associated with B-cell malignancies. EBNA-3C is critical for in vitro primary B-cell transformation. Interestingly, the N terminal domain of EBNA3C which contains residues 130–159, interacts with various cellular proteins, such as p53, Mdm2, CyclinD1...

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Detalles Bibliográficos
Autores principales: Shukla, Sanket Kumar, Jha, Hem Chandra, El-Naccache, Darine W., Robertson, Erle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951276/
https://www.ncbi.nlm.nih.gov/pubmed/26908453
http://dx.doi.org/10.18632/oncotarget.7502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951276/
https://www.ncbi.nlm.nih.gov/pubmed/26908453
http://dx.doi.org/10.18632/oncotarget.7502

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