CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles

The recently discovered CHK1-Suppressed (CS) pathway is activated by inhibition or loss of the checkpoint kinase CHK1, promoting an apoptotic response to DNA damage mediated by caspase-2 in p53-deficient cells. Although functions of the CS-pathway have been investigated biochemically, it remains unc...

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Detalles Bibliográficos
Autores principales: Carroll, Brittany L., Pulkoski-Gross, Michael J., Hannun, Yusuf A., Obeid, Lina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951279/
https://www.ncbi.nlm.nih.gov/pubmed/26921248
http://dx.doi.org/10.18632/oncotarget.7566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951279/
https://www.ncbi.nlm.nih.gov/pubmed/26921248
http://dx.doi.org/10.18632/oncotarget.7566

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