Cargando…

CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles

The recently discovered CHK1-Suppressed (CS) pathway is activated by inhibition or loss of the checkpoint kinase CHK1, promoting an apoptotic response to DNA damage mediated by caspase-2 in p53-deficient cells. Although functions of the CS-pathway have been investigated biochemically, it remains unc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carroll, Brittany L., Pulkoski-Gross, Michael J., Hannun, Yusuf A., Obeid, Lina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951279/ https://www.ncbi.nlm.nih.gov/pubmed/26921248 http://dx.doi.org/10.18632/oncotarget.7566

Ejemplares similares

A role for caspase‐2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells – implications for the CHK1‐suppressed pathway
por: Carroll, Brittany L., et al.
Publicado: (2017)

Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2
por: Xu, Ruijuan, et al.
Publicado: (2017)

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response
por: Xu, Ruijuan, et al.
Publicado: (2016)

Microvesicles Contribute to the Bystander Effect of DNA Damage
por: Lin, Xiaozeng, et al.
Publicado: (2017)

p53 oligomerization status as an indicator of sensitivity of p53-wildtype neuroblastomas to the combination of DNA damaging agent and Chk1 inhibitor
por: Levesque, Aime A., et al.
Publicado: (2022)

Defining a role for sphingosine kinase 1 in p53-dependent tumors
por: Heffernan-Stroud, Linda A., et al.
Publicado: (2011)

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
por: Yu, Xinfang, et al.
Publicado: (2020)

CHK2 kinase in the DNA damage response and beyond
por: Zannini, Laura, et al.
Publicado: (2014)

Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid
por: Velazquez, Fabiola N., et al.
Publicado: (2020)

Protective Effect of Follicle-Stimulating Hormone on DNA Damage of Chicken Follicular Granulosa Cells by Inhibiting CHK2/p53
por: Zhou, Shuo, et al.
Publicado: (2022)

Transcriptional Regulation of Sphingosine Kinase 1
por: Bonica, Joseph, et al.
Publicado: (2020)

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells
por: Manic, Gwenola, et al.
Publicado: (2018)

Inhibition of Caspases Inhibits the Release of Apoptotic Bodies: Bcl-2 Inhibits the Initiation of Formation of Apoptotic Bodies in Chemotherapeutic Agent-induced Apoptosis
por: Zhang, Jiandi, et al.
Publicado: (1999)

Rad53- and Chk1-Dependent DNA Damage Response Pathways Cooperatively Promote Fungal Pathogenesis and Modulate Antifungal Drug Susceptibility
por: Jung, Kwang-Woo, et al.
Publicado: (2019)

Chk1, Chk2, is the amplifier on?
por: Dove, Alan W.
Publicado: (2001)

Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation
por: Greenow, Kirsty R., et al.
Publicado: (2009)

Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention
por: Poltz, Rainer, et al.
Publicado: (2012)

Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage
por: Park, Caroline, et al.
Publicado: (2015)

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest
por: Shamseddine, A A, et al.
Publicado: (2015)

DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53-deficient pancreatic cancer cells
por: Jing, Wei, et al.
Publicado: (2018)

The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor
por: Liang, Xiaobing, et al.
Publicado: (2011)

AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells
por: Coant, Nicolas, et al.
Publicado: (2018)

DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1
por: Selvarajah, Jogitha, et al.
Publicado: (2014)

Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells
por: Origanti, Sofia, et al.
Publicado: (2012)

SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
por: Gioia, Ubaldo, et al.
Publicado: (2023)

Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress
por: Saini, Priyanka, et al.
Publicado: (2015)

Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells
por: Ando, Kiyohiro, et al.
Publicado: (2019)

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein
por: Day, Matthew, et al.
Publicado: (2021)

CHK2 is involved in the p53-independent radiosensitizing effects of valproic acid
por: Choo, Dong Wan, et al.
Publicado: (2017)

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation
por: Bétous, Rémy, et al.
Publicado: (2013)

DNA damage independent inhibition of NF-κB transcription by anthracyclines
por: Chora, Angelo Ferreira, et al.
Publicado: (2022)

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation
por: Zhao, Lihong, et al.
Publicado: (2011)

CTP sensing and Mec1(ATR)-Rad53(CHK1/CHK2) mediate a two-layered response to inhibition of glutamine metabolism
por: Ajazi, Arta, et al.
Publicado: (2022)

Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death
por: Del Nagro, Christopher J, et al.
Publicado: (2014)

Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer
por: Nair, Jayakumar, et al.
Publicado: (2020)

Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint
por: Qu, Meng, et al.
Publicado: (2012)

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage
por: Gong, Eun-Yeung, et al.
Publicado: (2015)

Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis
por: Magni, Martina, et al.
Publicado: (2014)

Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage
por: Massey, Andrew J.
Publicado: (2017)

Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells
por: Zhou, Xinhui, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_eddcrcnoaegf8rplsjd30epsg0