Dicer suppresses the malignant phenotype in VHL-deficient clear cell renal cell carcinoma by inhibiting HIF-2α

Both the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) pathway and microRNA (miRNA) regulation are important mechanisms underlying the development and progression of clear cell renal cell carcinoma (ccRCC). Here we demonstrate that VHL deficiency leads to downregulation of Dicer and, in tur...

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Detalles Bibliográficos
Autores principales: Fan, Yang, Li, Hongzhao, Ma, Xin, Gao, Yu, Bao, Xu, Du, Qingshan, Ma, Minghui, Liu, Kan, Yao, Yuanxin, Huang, Qingbo, Zhang, Yu, Zhang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951288/
https://www.ncbi.nlm.nih.gov/pubmed/26943772
http://dx.doi.org/10.18632/oncotarget.7807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951288/
https://www.ncbi.nlm.nih.gov/pubmed/26943772
http://dx.doi.org/10.18632/oncotarget.7807

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