Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response

Human cells respond to DNA damage by elevating sphingosine, a bioactive sphingolipid that induces programmed cell death (PCD) in response to various forms of stress, but its regulation and role in the DNA damage response remain obscure. Herein we demonstrate that DNA damage increases sphingosine lev...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Ruijuan, Wang, Kai, Mileva, Izolda, Hannun, Yusuf A., Obeid, Lina M., Mao, Cungui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951300/
https://www.ncbi.nlm.nih.gov/pubmed/26943039
http://dx.doi.org/10.18632/oncotarget.7825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951300/
https://www.ncbi.nlm.nih.gov/pubmed/26943039
http://dx.doi.org/10.18632/oncotarget.7825

Ejemplares similares