Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint

PURPOSE: Cdc7 is a serine/threonine kinase which is responsible for the ‘firing’ of replication origins leading to initiation of DNA replication. Inhibition or depletion of Cdc7 in normal cells triggers a DNA origin activation checkpoint causing a reversible G1 arrest. Here we investigate Cdc7 as a...

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Detalles Bibliográficos
Autores principales: Huggett, Matthew T., Tudzarova, Slavica, Proctor, Ian, Loddo, Marco, Keane, Margaret G., Stoeber, Kai, Williams, Gareth H., Pereira, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951304/
https://www.ncbi.nlm.nih.gov/pubmed/26921250
http://dx.doi.org/10.18632/oncotarget.7611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951304/
https://www.ncbi.nlm.nih.gov/pubmed/26921250
http://dx.doi.org/10.18632/oncotarget.7611

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