Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia

Survival of cancer cells relies on the unfolded protein response (UPR) to resist stress triggered by the accumulation of misfolded proteins within the endoplasmic reticulum (ER). The IRE1α-XBP1 pathway, a key branch of the UPR, is activated in many cancers. Here, we show that the expression of both...

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Detalles Bibliográficos
Autores principales: Sun, Haibo, Lin, De-Chen, Guo, Xiao, Masouleh, Behzad Kharabi, Gery, Sigal, Cao, Qi, Alkan, Serhan, Ikezoe, Takayuki, Akiba, Chie, Paquette, Ronald, Chien, Wenwen, Müller-Tidow, Carsten, Jing, Yang, Agelopoulos, Konstantin, Müschen, Markus, Koeffler, H. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951325/
https://www.ncbi.nlm.nih.gov/pubmed/26934650
http://dx.doi.org/10.18632/oncotarget.7702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951325/
https://www.ncbi.nlm.nih.gov/pubmed/26934650
http://dx.doi.org/10.18632/oncotarget.7702

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