Exogenous p53 and ASPP2 expression enhances rAdV-TK/GCV-induced death in hepatocellular carcinoma cells lacking functional p53

Suicide gene therapy using herpes simplex virus-1 thymidine kinase (HSV-TK) in combination with ganciclovir (GCV) has emerged as a potential new method for treating cancer. We hypothesize that the efficacy of HSV-TK/GCV therapy is at least partially dependent on p53 status in hepatocellular carcinom...

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Detalles Bibliográficos
Autores principales: Liu, Xiuhong, Wang, Shuang, Guo, Xianghua, Wei, Feili, Yin, Jiming, Zang, Yunjin, Li, Ning, Chen, Dexi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951338/
https://www.ncbi.nlm.nih.gov/pubmed/26934443
http://dx.doi.org/10.18632/oncotarget.7749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951338/
https://www.ncbi.nlm.nih.gov/pubmed/26934443
http://dx.doi.org/10.18632/oncotarget.7749

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