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Exogenous p53 and ASPP2 expression enhances rAdV-TK/GCV-induced death in hepatocellular carcinoma cells lacking functional p53

Suicide gene therapy using herpes simplex virus-1 thymidine kinase (HSV-TK) in combination with ganciclovir (GCV) has emerged as a potential new method for treating cancer. We hypothesize that the efficacy of HSV-TK/GCV therapy is at least partially dependent on p53 status in hepatocellular carcinom...

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Detalles Bibliográficos
Autores principales:	Liu, Xiuhong, Wang, Shuang, Guo, Xianghua, Wei, Feili, Yin, Jiming, Zang, Yunjin, Li, Ning, Chen, Dexi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951338/ https://www.ncbi.nlm.nih.gov/pubmed/26934443 http://dx.doi.org/10.18632/oncotarget.7749

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