Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1

Metformin and the mitochondrial targeting dichloroacetate (DCA) have recently received attention due to their ability to inhibit anaerobic glycolysis, which renders most cancer cells resistant to apoptosis induction. We observed that Metformin alone exhibited a dose-dependent anti-leukemic activity...

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Detalles Bibliográficos
Autores principales: Voltan, Rebecca, Rimondi, Erika, Melloni, Elisabetta, Gilli, Paola, Bertolasi, Valerio, Casciano, Fabio, Rigolin, Gian Matteo, Zauli, Giorgio, Secchiero, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951344/
https://www.ncbi.nlm.nih.gov/pubmed/26959881
http://dx.doi.org/10.18632/oncotarget.7879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951344/
https://www.ncbi.nlm.nih.gov/pubmed/26959881
http://dx.doi.org/10.18632/oncotarget.7879

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