ZLM-7 exhibits anti-angiogenic effects via impaired endothelial cell function and blockade of VEGF/VEGFR-2 signaling

Inhibition of angiogenesis is a promising therapeutic strategy against cancer. In this study, we reported that ZLM-7, a combretastain A-4 (CA-4) derivative, exhibited anti-angiogenic activity in vitro and in vivo. In vitro, ZLM-7 induced microtubule cytoskeletal disassembly. It decreased VEGF-induce...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Min, Huang, Jingjia, Li, Jijia, Qin, Xiyuan, Tang, Xiaoning, Jin, Fang, Chen, Shali, Jiang, Chuanming, Zou, Zizheng, Peng, Kunjian, Nuruzzaman, Mohammed, Zhang, Jianting, Luo, Junli, Liu, Suyou, Luo, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951348/
https://www.ncbi.nlm.nih.gov/pubmed/26967559
http://dx.doi.org/10.18632/oncotarget.7968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951348/
https://www.ncbi.nlm.nih.gov/pubmed/26967559
http://dx.doi.org/10.18632/oncotarget.7968

Ejemplares similares