Cargando…

ZLM-7 exhibits anti-angiogenic effects via impaired endothelial cell function and blockade of VEGF/VEGFR-2 signaling

Inhibition of angiogenesis is a promising therapeutic strategy against cancer. In this study, we reported that ZLM-7, a combretastain A-4 (CA-4) derivative, exhibited anti-angiogenic activity in vitro and in vivo. In vitro, ZLM-7 induced microtubule cytoskeletal disassembly. It decreased VEGF-induce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Su, Min, Huang, Jingjia, Li, Jijia, Qin, Xiyuan, Tang, Xiaoning, Jin, Fang, Chen, Shali, Jiang, Chuanming, Zou, Zizheng, Peng, Kunjian, Nuruzzaman, Mohammed, Zhang, Jianting, Luo, Junli, Liu, Suyou, Luo, Zhiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951348/ https://www.ncbi.nlm.nih.gov/pubmed/26967559 http://dx.doi.org/10.18632/oncotarget.7968

Ejemplares similares

The anti-angiogenic effect and novel mechanisms of action of Combretastatin A-4
por: Su, Min, et al.
Publicado: (2016)

Ginsenoside metabolite 20(S)-protopanaxadiol promotes neural stem cell transition from a state of proliferation to differentiation by inducing autophagy and cell cycle arrest
por: Chen, Shali, et al.
Publicado: (2020)

Anti-angiogenic alternatives to VEGF blockade
por: Khan, Kabir A., et al.
Publicado: (2015)

Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
por: Zou, Zizheng, et al.
Publicado: (2021)

An Isoxazoloquinone Derivative Inhibits Tumor Growth by Targeting STAT3 and Triggering Its Ubiquitin-Dependent Degradation
por: Xie, Yuanzhu, et al.
Publicado: (2023)

Old Player-New Tricks: Non Angiogenic Effects of the VEGF/VEGFR Pathway in Cancer
por: Ntellas, Panagiotis, et al.
Publicado: (2020)

ZLM-7 Blocks Breast Cancer Progression by Inhibiting MDM2 via Upregulation of 14-3-3 Sigma
por: Wen, Min, et al.
Publicado: (2022)

Transcriptome Analysis of Methyl Jasmonate-Elicited Panax ginseng Adventitious Roots to Discover Putative Ginsenoside Biosynthesis and Transport Genes
por: Cao, Hongzhe, et al.
Publicado: (2015)

Draft Genome Sequence of Nafulsella turpanensis ZLM-10(T), a Novel Member of the Family Flammeovirgaceae
por: Zhang, Lei, et al.
Publicado: (2014)

Celecoxib alleviates tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling
por: Kumar, B N Prashanth, et al.
Publicado: (2013)

Salinomycin exhibits anti-angiogenic activity against human glioma in vitro and in vivo by suppressing the VEGF-VEGFR2-AKT/FAK signaling axis
por: Bi, Yan-Ling, et al.
Publicado: (2017)

ZLM-7 inhibits the occurrence and angiogenesis of breast cancer through miR-212-3p/Sp1/VEGFA signal axis
por: Li, Xuan, et al.
Publicado: (2020)

Association between VEGF-A and VEGFR-2 polymorphisms and response to treatment of neovascular AMD with anti-VEGF agents: a meta-analysis
por: Wu, Mingxing, et al.
Publicado: (2017)

Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling
por: Ragunathrao, Vijay Avin Balaji, et al.
Publicado: (2019)

VEGF-VEGFR Signals in Health and Disease
por: Shibuya, Masabumi
Publicado: (2014)

Acidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies
por: Faes, Seraina, et al.
Publicado: (2016)

Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression
por: Wang, Min, et al.
Publicado: (2019)

Changes in the Expression Profile of VEGF-A, VEGF-B, VEGFR-1, VEGFR-2 in Different Grades of Endometrial Cancer
por: Dziobek, Konrad, et al.
Publicado: (2019)

Molecular Cloning and Expression Analysis of Eight PgWRKY Genes in Panax ginseng Responsive to Salt and Hormones
por: Xiu, Hao, et al.
Publicado: (2016)

Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies
por: Meng, Qian, et al.
Publicado: (2016)

Ginsenoside Rh2 inhibits breast cancer cell growth viaERβ-TNFα pathway: Ginsenoside Rh2 inhibits breast cancer cell growth via ERβ-TNFα
por: Peng, Kunjian, et al.
Publicado: (2022)

Targeting VEGF/VEGFR to Modulate Antitumor Immunity
por: Yang, Ju, et al.
Publicado: (2018)

Diagnostic Value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline Mammary Carcinoma
por: Nascimento, Catarina, et al.
Publicado: (2021)

Suppressing VEGF-A/VEGFR-2 Signaling Contributes to the Anti-Angiogenic Effects of PPE8, a Novel Naphthoquinone-Based Compound
por: Hsu, Ming-Jen, et al.
Publicado: (2022)

Inhibition of LPA-LPAR1 and VEGF-VEGFR2 Signaling in IPF Treatment
por: Luo, Ya-Li, et al.
Publicado: (2023)

Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
por: Hwang, Jun-Eul, et al.
Publicado: (2013)

Notch regulates the angiogenic response via induction of VEGFR-1
por: Funahashi, Yasuhiro, et al.
Publicado: (2010)

VEGF-dependent tumor angiogenesis requires the inverse and reciprocal regulation of VEGFR1 and VEGFR2
por: Zhang, Zhaocheng, et al.
Publicado: (2009)

Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling
por: Toivanen, Pyry I., et al.
Publicado: (2017)

Genetic variations in VEGF and VEGFR2 and glioblastoma outcome
por: Sjöström, S., et al.
Publicado: (2010)

Counterbalance: modulation of VEGF/VEGFR activities by TNFSF15
por: Yang, Gui-Li, et al.
Publicado: (2018)

The VEGF/VEGFR Axis Revisited: Implications for Cancer Therapy
por: Mabeta, Peace, et al.
Publicado: (2022)

Structure-Based Design of Peptides Targeting VEGF/VEGFRs
por: Di Stasi, Rossella, et al.
Publicado: (2023)

Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin
por: Rusnati, Marco, et al.
Publicado: (2021)

Effects of oestradiol and tamoxifen on VEGF, soluble VEGFR-1, and VEGFR-2 in breast cancer and endothelial cells
por: Garvin, S, et al.
Publicado: (2005)

VEGF(121)b and VEGF(165)b are weakly angiogenic isoforms of VEGF-A
por: Catena, Raúl, et al.
Publicado: (2010)

The role of the VEGF-C/VEGFR-3 axis in cancer progression
por: Su, J-L, et al.
Publicado: (2007)

The Role of the VEGF-C/VEGFRs Axis in Tumor Progression and Therapy
por: Chen, Jui-Chieh, et al.
Publicado: (2012)

Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?
por: Li, Yu-Ling, et al.
Publicado: (2016)

VEGF-A splice variants bind VEGFRs with differential affinities
por: Mamer, Spencer B., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vrdpfbi29l62f8rlmj6kmqs0vo