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Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides
Brain delivery of macromolecular therapeutics (e.g., proteins) remains an unsolved problem because of the formidable blood–brain barrier (BBB). Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain deli...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951590/ https://www.ncbi.nlm.nih.gov/pubmed/27471676 http://dx.doi.org/10.1016/j.apsb.2016.04.001 |