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Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides

Brain delivery of macromolecular therapeutics (e.g., proteins) remains an unsolved problem because of the formidable blood–brain barrier (BBB). Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain deli...

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Detalles Bibliográficos
Autores principales: Lin, Tingting, Liu, Ergang, He, Huining, Shin, Meong Cheol, Moon, Cheol, Yang, Victor C., Huang, Yongzhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951590/
https://www.ncbi.nlm.nih.gov/pubmed/27471676
http://dx.doi.org/10.1016/j.apsb.2016.04.001