Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5

Sirtuin 5 (SIRT5) is a mitochondrial-localized NAD(+)-dependent lysine desuccinylase and a major regulator of the mitochondrial succinylome. We wanted to determine whether SIRT5 is activated by protein kinase C epsilon (PKCε)-mediated increases in mitochondrial Nampt and whether SIRT5 regulates mito...

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Detalles Bibliográficos
Autores principales: Morris-Blanco, Kahlilia C., Dave, Kunjan R., Saul, Isabel, Koronowski, Kevin B., Stradecki, Holly M., Perez-Pinzon, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951704/
https://www.ncbi.nlm.nih.gov/pubmed/27435822
http://dx.doi.org/10.1038/srep29790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951704/
https://www.ncbi.nlm.nih.gov/pubmed/27435822
http://dx.doi.org/10.1038/srep29790

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