Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex

Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. However, resistance to this class of drugs, particularly in the major human mould pathogen Aspergillus fumigatus, is emerging and reaching levels that have prompted some to suggest that...

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Detalles Bibliográficos
Autores principales: Gsaller, Fabio, Hortschansky, Peter, Furukawa, Takanori, Carr, Paul D., Rash, Bharat, Capilla, Javier, Müller, Christoph, Bracher, Franz, Bowyer, Paul, Haas, Hubertus, Brakhage, Axel A., Bromley, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954732/
https://www.ncbi.nlm.nih.gov/pubmed/27438727
http://dx.doi.org/10.1371/journal.ppat.1005775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954732/
https://www.ncbi.nlm.nih.gov/pubmed/27438727
http://dx.doi.org/10.1371/journal.ppat.1005775

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