Insights into Mucopolysaccharidosis I from the structure and action of α-L-Iduronidase

Mucopolysaccharidosis type I (MPS I), caused by mutations in the gene encoding α-L-iduronidase (IDUA), is one of approximately 70 genetic disorders collectively known as the lysosomal storage diseases. To gain insight into the basis for MPS I, we have crystallized human IDUA produced in an Arabidops...

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Detalles Bibliográficos
Autores principales: Bie, Haiying, Yin, Jiang, He, Xu, Kermode, Allison R., Goddard-Borger, Ethan D., Withers, Stephen G., James, Michael N. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954775/
https://www.ncbi.nlm.nih.gov/pubmed/24036510
http://dx.doi.org/10.1038/nchembio.1357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954775/
https://www.ncbi.nlm.nih.gov/pubmed/24036510
http://dx.doi.org/10.1038/nchembio.1357

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