Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

RAF kinases play a prominent role in cancer. Their mode of activation is complex, but critically requires dimerization of their kinase domains. Unexpectedly, several ATP-competitive RAF inhibitors were recently found to promote dimerization and transactivation of RAF kinases in a RAS-dependent manne...

Descripción completa

Detalles Bibliográficos
Autores principales: Lavoie, Hugo, Thevakumaran, Neroshan, Gavory, Gwenaëlle, Li, John, Padeganeh, Abbas, Guiral, Sébastien, Duchaine, Jean, Mao, Daniel Y. L., Bouvier, Michel, Sicheri, Frank, Therrien, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954776/
https://www.ncbi.nlm.nih.gov/pubmed/23685672
http://dx.doi.org/10.1038/nchembio.1257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954776/
https://www.ncbi.nlm.nih.gov/pubmed/23685672
http://dx.doi.org/10.1038/nchembio.1257

Ejemplares similares