Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice

Lisofylline (LSF), is the R-(−) enantiomer of the metabolite M1 of pentoxifylline, and is currently under development for the treatment of type 1 diabetes. The aim of the study was to develop a physiologically based pharmacokinetic (PBPK) model of LSF in mice and to perform simulations in order to p...

Descripción completa

Detalles Bibliográficos
Autores principales: Wyska, Elżbieta, Świerczek, Artur, Pociecha, Krzysztof, Przejczowska-Pomierny, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954844/
https://www.ncbi.nlm.nih.gov/pubmed/25663650
http://dx.doi.org/10.1007/s13318-015-0260-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954844/
https://www.ncbi.nlm.nih.gov/pubmed/25663650
http://dx.doi.org/10.1007/s13318-015-0260-y

Ejemplares similares