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Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice

Lisofylline (LSF), is the R-(−) enantiomer of the metabolite M1 of pentoxifylline, and is currently under development for the treatment of type 1 diabetes. The aim of the study was to develop a physiologically based pharmacokinetic (PBPK) model of LSF in mice and to perform simulations in order to p...

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Detalles Bibliográficos
Autores principales:	Wyska, Elżbieta, Świerczek, Artur, Pociecha, Krzysztof, Przejczowska-Pomierny, Katarzyna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2015
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954844/ https://www.ncbi.nlm.nih.gov/pubmed/25663650 http://dx.doi.org/10.1007/s13318-015-0260-y

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