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MicroRNA-mediated target mRNA cleavage and 3′-uridylation in human cells

MicroRNAs (miRNAs) play an important role in targeted gene silencing by facilitating posttranscriptional and translational repression. However, the precise mechanism of mammalian miRNA-mediated gene silencing remains to be elucidated. Here, we used a stem-loop array reverse-transcription polymerase...

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Detalles Bibliográficos
Autores principales: Xu, Kai, Lin, Jing, Zandi, Roza, Roth, Jack A., Ji, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954961/
https://www.ncbi.nlm.nih.gov/pubmed/27440378
http://dx.doi.org/10.1038/srep30242