Liquid chromatography–mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients

Adverse reactions and non-response are common in patients treated with thiopurine drugs. Current monitoring of drug metabolite levels for guiding treatment are limited to analysis of thioguanine nucleotides (TGNs) in erythrocytes after chemical derivatisation. Erythrocytes are not the target tissue...

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Detalles Bibliográficos
Autores principales: Coulthard, Sally A., Berry, Phil, McGarrity, Sarah, Ansari, Azhar, Redfern, Christopher P.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955110/
https://www.ncbi.nlm.nih.gov/pubmed/27362994
http://dx.doi.org/10.1016/j.jchromb.2016.06.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955110/
https://www.ncbi.nlm.nih.gov/pubmed/27362994
http://dx.doi.org/10.1016/j.jchromb.2016.06.017

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