An AKT3-FOXG1-Reelin Network Underlies Defective Migration in Human Focal Malformations of Cortical Development

Focal malformations of cortical development (FMCD) account for the majority of drug-resistant pediatric epilepsy. Postzygotic somatic mutations activating the PI3K-AKT-mTOR pathway are found in a wide range of brain diseases, including FMCD. It remains unclear how a mutation in a small fraction of c...

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Detalles Bibliográficos
Autores principales: Baek, Seung Tae, Copeland, Brett, Yun, Eun-Jin, Kwon, Seok-Kyu, Guemez-Gamboa, Alicia, Schaffer, Ashleigh E., Kim, Sangwoo, Kang, Hoon-Chul, Song, Saera, Mathern, Gary W., Gleeson, Joseph G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955611/
https://www.ncbi.nlm.nih.gov/pubmed/26523971
http://dx.doi.org/10.1038/nm.3982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955611/
https://www.ncbi.nlm.nih.gov/pubmed/26523971
http://dx.doi.org/10.1038/nm.3982

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