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Specialized proteasome subunits play an essential role in thymic selection of CD8(+) T cells
The cells that stimulate positive selection express different specialized proteasome β-subunits than all other cells, including those involved in negative selection. Mice that lack all four specialized proteasome β-subunits, and therefore express only constitutive proteasomes in all cells, had a pro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955723/ https://www.ncbi.nlm.nih.gov/pubmed/27294792 http://dx.doi.org/10.1038/ni.3480 |
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author | Kincaid, Eleanor Z. Murata, Shigeo Tanaka, Keiji Rock, Kenneth L. |
author_facet | Kincaid, Eleanor Z. Murata, Shigeo Tanaka, Keiji Rock, Kenneth L. |
author_sort | Kincaid, Eleanor Z. |
collection | PubMed |
description | The cells that stimulate positive selection express different specialized proteasome β-subunits than all other cells, including those involved in negative selection. Mice that lack all four specialized proteasome β-subunits, and therefore express only constitutive proteasomes in all cells, had a profound defect in the generation of CD8(+) T cells. While a defect in positive selection would reflect an inability to generate the appropriate positively selecting peptides, a block at negative selection would point to the potential need to switch peptides between positive and negative selection to avoid the two processes often cancelling each other out. We found that the block in T cell development occurred around the checkpoints of positive and, surprisingly, also negative selection. |
format | Online Article Text |
id | pubmed-4955723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
record_format | MEDLINE/PubMed |
spelling | pubmed-49557232016-12-13 Specialized proteasome subunits play an essential role in thymic selection of CD8(+) T cells Kincaid, Eleanor Z. Murata, Shigeo Tanaka, Keiji Rock, Kenneth L. Nat Immunol Article The cells that stimulate positive selection express different specialized proteasome β-subunits than all other cells, including those involved in negative selection. Mice that lack all four specialized proteasome β-subunits, and therefore express only constitutive proteasomes in all cells, had a profound defect in the generation of CD8(+) T cells. While a defect in positive selection would reflect an inability to generate the appropriate positively selecting peptides, a block at negative selection would point to the potential need to switch peptides between positive and negative selection to avoid the two processes often cancelling each other out. We found that the block in T cell development occurred around the checkpoints of positive and, surprisingly, also negative selection. 2016-06-13 2016-08 /pmc/articles/PMC4955723/ /pubmed/27294792 http://dx.doi.org/10.1038/ni.3480 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Kincaid, Eleanor Z. Murata, Shigeo Tanaka, Keiji Rock, Kenneth L. Specialized proteasome subunits play an essential role in thymic selection of CD8(+) T cells |
title | Specialized proteasome subunits play an essential role in thymic selection of CD8(+) T cells |
title_full | Specialized proteasome subunits play an essential role in thymic selection of CD8(+) T cells |
title_fullStr | Specialized proteasome subunits play an essential role in thymic selection of CD8(+) T cells |
title_full_unstemmed | Specialized proteasome subunits play an essential role in thymic selection of CD8(+) T cells |
title_short | Specialized proteasome subunits play an essential role in thymic selection of CD8(+) T cells |
title_sort | specialized proteasome subunits play an essential role in thymic selection of cd8(+) t cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955723/ https://www.ncbi.nlm.nih.gov/pubmed/27294792 http://dx.doi.org/10.1038/ni.3480 |
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