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Specialized proteasome subunits play an essential role in thymic selection of CD8(+) T cells

The cells that stimulate positive selection express different specialized proteasome β-subunits than all other cells, including those involved in negative selection. Mice that lack all four specialized proteasome β-subunits, and therefore express only constitutive proteasomes in all cells, had a pro...

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Detalles Bibliográficos
Autores principales: Kincaid, Eleanor Z., Murata, Shigeo, Tanaka, Keiji, Rock, Kenneth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955723/
https://www.ncbi.nlm.nih.gov/pubmed/27294792
http://dx.doi.org/10.1038/ni.3480