Cyclophilin Inhibitors Remodel the Endoplasmic Reticulum of HCV-Infected Cells in a Unique Pattern Rendering Cells Impervious to a Reinfection

The mechanisms of action by which cyclophilin inhibitors (CypI) interfere with the HCV life cycle remain poorly understood. We reported that CypI and NS5A inhibitors (NS5Ai), but not other classes of anti-HCV agents, prevent assembly of double membrane vesicles (DMVs), which protect replication comp...

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Detalles Bibliográficos
Autores principales: Chatterji, Udayan, Bobardt, Michael, Schaffer, Lana, Wood, Malcolm, Gallay, Philippe A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956074/
https://www.ncbi.nlm.nih.gov/pubmed/27442520
http://dx.doi.org/10.1371/journal.pone.0159511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956074/
https://www.ncbi.nlm.nih.gov/pubmed/27442520
http://dx.doi.org/10.1371/journal.pone.0159511

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