Cargando…

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase

Fatty-acid amide hydrolase (FAAH) is the major enzyme responsible for degradation of anandamide, an endocannabinoid. Pharmacological inhibition or genetic deletion of FAAH (FAAH KO) produces antinociception in preclinical pain models that is largely attributed to anandamide-induced activation of can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carey, Lawrence M, Slivicki, Richard A, Leishman, Emma, Cornett, Ben, Mackie, Ken, Bradshaw, Heather, Hohmann, Andrea G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956176/ https://www.ncbi.nlm.nih.gov/pubmed/27178246 http://dx.doi.org/10.1177/1744806916649192

Ejemplares similares

Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice
por: Carey, Lawrence M., et al.
Publicado: (2017)

Elevated Levels of Arachidonic Acid-Derived Lipids Including Prostaglandins and Endocannabinoids Are Present Throughout ABHD12 Knockout Brains: Novel Insights Into the Neurodegenerative Phenotype
por: Leishman, Emma, et al.
Publicado: (2019)

Voluntary exercise reduces both chemotherapy-induced neuropathic nociception and deficits in hippocampal cellular proliferation in a mouse model of paclitaxel-induced peripheral neuropathy
por: Slivicki, Richard A., et al.
Publicado: (2019)

Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study
por: Björklund, Emmelie, et al.
Publicado: (2014)

Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors
por: Kodani, Sean D., et al.
Publicado: (2018)

Epigenetic Regulation of Fatty Acid Amide Hydrolase in Alzheimer Disease
por: D'Addario, Claudio, et al.
Publicado: (2012)

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors
por: Deplano, Alessandro, et al.
Publicado: (2019)

Luciferin Amides Enable in Vivo Bioluminescence Detection of Endogenous Fatty Acid Amide Hydrolase Activity
por: Mofford, David M., et al.
Publicado: (2015)

Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen
por: Deplano, Alessandro, et al.
Publicado: (2020)

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase
por: Qiu, Yan, et al.
Publicado: (2016)

Role of Steroids on the Membrane Binding Ability of Fatty Acid Amide Hydrolase
por: Sabatucci, Annalaura, et al.
Publicado: (2019)

Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains
por: Leishman, Emma, et al.
Publicado: (2018)

Cannabidiol's Upregulation of N-acyl Ethanolamines in the Central Nervous System Requires N-acyl Phosphatidyl Ethanolamine-Specific Phospholipase D
por: Leishman, Emma, et al.
Publicado: (2018)

Cellular viability effects of fatty acid amide hydrolase inhibition on cerebellar neurons
por: Lueneberg, Kathia, et al.
Publicado: (2011)

Overexpression of Fatty Acid Amide Hydrolase Induces Early Flowering in Arabidopsis thaliana
por: Teaster, Neal D., et al.
Publicado: (2012)

Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis
por: Rieck, Sarah, et al.
Publicado: (2021)

Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer
por: Tundidor, Isabel, et al.
Publicado: (2023)

Fatty Acid Amide Hydrolase (FAAH) Inhibitors Exert Pharmacological Effects, but Lack Antinociceptive Efficacy in Rats with Neuropathic Spinal Cord Injury Pain
por: Hama, Aldric T., et al.
Publicado: (2014)

Chronic Adolescent Δ(9)-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment
por: Murphy, Michelle, et al.
Publicado: (2017)

Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice
por: Cassano, Tommaso, et al.
Publicado: (2010)

Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms
por: Sirrs, Sandra, et al.
Publicado: (2015)

Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants
por: Ogawa, Shintaro, et al.
Publicado: (2015)

PET Imaging of Fatty Acid Amide Hydrolase with [(18)F]DOPP in Nonhuman Primates
por: Rotstein, Benjamin H., et al.
Publicado: (2014)

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition
por: Palermo, Giulia, et al.
Publicado: (2015)

The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding
por: Sekiba, Kazuma, et al.
Publicado: (2020)

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10‐2474
por: Bonifácio, Maria‐João, et al.
Publicado: (2020)

Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation
por: Green, Duncan GJ., et al.
Publicado: (2022)

Selective Ablation of Descending Serotonin from the Rostral Ventromedial Medulla Unmasks Its Pro-Nociceptive Role in Chemotherapy-Induced Painful Neuropathy
por: Liu, Xijiang, et al.
Publicado: (2020)

Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population
por: Ando, Tetsuya, et al.
Publicado: (2014)

Dysfunction in Fatty Acid Amide Hydrolase Is Associated with Depressive-Like Behavior in Wistar Kyoto Rats
por: Vinod, K. Yaragudri, et al.
Publicado: (2012)

A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain
por: Benson, N, et al.
Publicado: (2014)

Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice
por: Helfand, Alexander I., et al.
Publicado: (2017)

In Silico and In Vitro Analysis of Major Cannabis-Derived Compounds as Fatty Acid Amide Hydrolase Inhibitors
por: Criscuolo, Emanuele, et al.
Publicado: (2020)

Para-Aminobenzohydrazide Derivatives as Fatty Acid Amide Hydrolase Inhibitors: Design, Synthesis and Biological Evaluation
por: Sedaghat, Anna, et al.
Publicado: (2020)

Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization
por: Grieco, Maddalena, et al.
Publicado: (2021)

Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats
por: Zubrzycki, Marek, et al.
Publicado: (2022)

Cocaine-induced loss of LTD and social impairments are restored by fatty acid amide hydrolase inhibition
por: Alegre-Zurano, Laia, et al.
Publicado: (2023)

Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro
por: Dongdem, Julius T., et al.
Publicado: (2022)

Pro-neurotrophins, sortilin, and nociception
por: Lewin, Gary R, et al.
Publicado: (2014)

Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury
por: Pardini, M, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_vcb9jqgj9pkfhlil1fgdat0l04