p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation

The catalytical isoforms p110γ and p110δ of phosphatidylinositide 3-kinase γ (PI3Kγ) and PI3Kδ play an important role in the pathogenesis of asthma. Two key elements in allergic asthma are increased levels of eosinophils and IgE. Dual pharmacological inhibition of p110γ and p110δ reduces asthma-asso...

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Detalles Bibliográficos
Autores principales: Mothes, Benedikt, Bucher, Kirsten, Ammon-Treiber, Susanne, Schwab, Matthias, Piekorz, Roland P., Hirsch, Emilio, Nürnberg, Bernd, Beer-Hammer, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956235/
https://www.ncbi.nlm.nih.gov/pubmed/27442134
http://dx.doi.org/10.1371/journal.pone.0159310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956235/
https://www.ncbi.nlm.nih.gov/pubmed/27442134
http://dx.doi.org/10.1371/journal.pone.0159310

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