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Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis
BACKGROUND: Cardiac fibrosis attributed to excessive deposition of extracellular matrix proteins is a major cause of heart failure and death. Cardiac fibrosis is extremely difficult and challenging to treat in a clinical setting due to lack of understanding of molecular mechanisms leading to cardiac...
Autores principales: | Groenendyk, Jody, Lee, Dukgyu, Jung, Joanna, Dyck, Jason R. B., Lopaschuk, Gary D., Agellon, Luis B., Michalak, Marek |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956237/ https://www.ncbi.nlm.nih.gov/pubmed/27441395 http://dx.doi.org/10.1371/journal.pone.0159682 |
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