Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs

Single stranded oligonucleotides (SSO) represent a novel therapeutic modality that opens new space to address previously undruggable targets. In spite of their proven efficacy, the development of promising SSO drug candidates has been limited by reported cases of SSO-associated hepatotoxicity. The m...

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Detalles Bibliográficos
Autores principales: Sewing, Sabine, Boess, Franziska, Moisan, Annie, Bertinetti-Lapatki, Cristina, Minz, Tanja, Hedtjaern, Maj, Tessier, Yann, Schuler, Franz, Singer, Thomas, Roth, Adrian B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956313/
https://www.ncbi.nlm.nih.gov/pubmed/27442522
http://dx.doi.org/10.1371/journal.pone.0159431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956313/
https://www.ncbi.nlm.nih.gov/pubmed/27442522
http://dx.doi.org/10.1371/journal.pone.0159431

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